Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells Full Text
Molecular Cancer, 01/05/2013

Furukawa T et al. – Pancreatic cancer is characterized by constitutive activation of mitogen–activated protein kinase (MAPK). Activation of MAPK is associated with the upregulation of genes implicated in the proliferation and survival of pancreatic cancer cells. The authors hypothesized that knockdown of these MAPK–associated molecules could produce notable anticancer phenotypes. The results indicate that SON plays a critical role in the proliferation, survival, and tumorigenicity of pancreatic cancer cells, suggesting that SON is a novel therapeutic molecular target for pancreatic cancer.