Thursday, February 28, 2013

GENES INVOLVED IN AML
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AML-1 - EAP/MDS-1  /EVI-1
CALM - FIO
AML-1  - ETO
PML- RAR
PLZF - RAR
CBF beta - MYH-11
NUP 98 -DDX 10
NUP 98 - HOXA 9
MOZ -  CBP
MLL
NPM - MLF-1
DEK - CAN
SET - CAN
TLS/FUS - ERG
P53 - ARF pathway
sp 100
MRP 8

TIF 2: TRANSCRIPTION INTERMEDIATE FACTOR 2
-------------------------------------------------------------A nuclear protein complex containing a Histone deacethyl transferase and a receptor to steroids which attachs Glucocorticoid, Estrogen (BRCA-1)and facilitate DNA transcription.
Also known as Nuclear Receptor Coactivator2 NCOA-2
Overexpression of TIF or mutaion here may have an impact on one of the subunit of Cytochrome-C,
It is a ligand (other ligand SRC-1, AIB-1).  It may help in tolerance of certain stressful milieu!
Is TIF 2 a biomarker for steroid response?
does TIF2 Mutation compromise effectiveness of ATRA in APL
what the role or interaction with NACA

FLIT 3
KIT
RAS
RUNX 1
EBP alpha
GATA-1
MLL-ENL FUSION
WASP
AFX
MEIS-1
HOXD-13
SMMHC, Smooth Muscle Myosin related marker of differentiation, but also imply use of multiple regulatory genes that ultimately depress P53 as a way to decrease repair of DNA and allow leukemia to proceed with proliferation. this marker is als see in Inv-16 Leukemia.  Through interaction with SMAD3, it affect TGF driven migration of leukemic cells.  It also interfere with ACTA 2, TGFBR-2 AND FBN-1,
THIS SUGGEST THAT BLOCKING MIGRATION AND IMMUNE BETA-2 RECEPTOR OF TGF COULD ADD TO ACUTE EOSINOPHILIC LEUKEMIA.  BLOCKING NUCLEAR INTERNALIZATION OF THE BETA SUBUNIT OF THE CBF WOULD HELP IN THE CBF DRIVEN LEUKEMIA IN GENERAL
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