STAT-1 DEPRESSION COULD PREDICT SUSCEPTIBILITY TO  HISTONE DEACYLASE AND KILLING THROUGH UPREGULATION OF Fas PATHWAY.

We have recently presented a case of a 38 YOF diagnosed with an unresectable Angiosarcoma
Her tumor was positive for factor 8, CD31, CD34 ad Ki-67.   This immunostaining profile was used to support the reading of the pathologist,  CD31, a platelet adhesion molecule (PECAM-1) is extensively found on the endothelial cells.  But the presence of factor 8 raises the possibility of Interferon Regulated Factor 8 (IRF8),   Therapeutically this would be interesting because not only it raises the possibility of Using Interferon gamma in this woman, but also Histone Deacetylators.

Our question, DOES EXPRESSION OF FACTOR 8 SUGGESTS SUSCEPTIBILITY TO HISTONE DEACETYLASE AND KILLING THROUGH UPREGULATION OF Fas IN PATIENT WITH STAT-1 DEPRESSION.

IT IS ESTABLISHED THAT INTERFERON HAS SOME ACTIVITY IN ANGIOSARCOMA, AND SO DOES ALL ANTI-VEGF AND POTENTIALLY ALL ANTI-MEK