SPLICEOSOME MACHINERY AND MYELOID MALIGNANCIES
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Spliceosome

From Wikipedia,

A spliceosome is a complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA (hnRNA) segment. This process is generally referred to as splicing.
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Spliceosome contains 300 different proteins and 5 RNAs (U1-6). making a very large complex.
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In Myeliod Malignancies, Hamilton et al. reported that Spliceosomal Mutations had prognostic implications in patients undergoing Hematopoietic Cell Transplantation.

SF3B1  having the better survival in MDS patients while
Mutants in SRSF and U2AF1 had worse prognosis.  Transplant is more indicated in these!
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WE DISCUSSED HOW SPLICING IS INCLUDED IN DIFFERENTIATION BECAUSE WHERE IT OCCURS DETERMINES THE LENGTH, NATURE AND MORPHOLOGY OF THE RESULTING PROTEINS.