MTOR INHIBITOR, changing Oncology practice,

I confess that after the Taxanes and Velcade,  the MTOR inhibitors are one of the most powerful drugs that came to the market, inducing critical change in oncology clinical practice.  It seems that if you have resistance to Hormone, the MTOR inhibitors answer the call and break the barrier, if you meet resistance to Octreotide in Neuroendocrine disease, the MTOR inhibitors emerge with an answer, if you are dealing with a refractory condition such as clear cell renal cell cancer, go to MTOR inhibitors. And the list is rapidly growing as we move forward.
When you look at the site of action, you quickly understand why.  Not only do they take their momentum deep into the nucleus (FOXO 3 and crisscross with the deep MYC amplification pathways), it has also Mitochondrial effects!  I believe this is why it is so effective!  The MTOR inhibitors, harvesting new ways to Caspases and Apoptosis.  Cure is still within reach!