DEPRESSION OF GENE ACTIVITY MORE OF A SIGN OF ONCOGENESIS

We have been asked to comment one more time about further evidence that depression of gen activity is more of a sign that it has induced cancer.
When we discuss that a gene is mutated, more times then not we are describing a situation where a gene ceases its function.  An example would be P53 Mutation where it stops its function, and alteration in DNA does not cause cell cycle arrest.
Another situation where P53 is wild type and normal, is the depression of MDM2 which lift inhibitory influence on P53.

Depression of PTEN is the inducer of Integrins activation and of the PI3K and MAP kinases.
Drop in STAT1 has been reported in triple negative Breast cancer
in BRCA, depression in gene repair could be the trigger
MYC depression or Mutation has been implicate in Oncogenesis although it is more of an amplifier of at least 15% of genes, and can amplify itself in Burkit and other small cell diseases

So yes gene depression is more Ominous in that regard.  Most of the amplification are secondary (unles it is a driver Mutation)!