Friday, March 29, 2013

DISCUSSING GENES IN ESOPHAGEAL CANCERS

* Esophageal cancers varies by types, and types are related to location
with the squamous cell cancer involving most of the upper 2 thirds of the Esophagus. It is this cancer that is linked to patients who are black, to Achalasia, caustic injury, Plummer -Vinson disease smoking and excessive alcohol consumption and to HPV.  Adenocarcinoma are linked to GERD, Barrettt Esophagus, white race, smoking and obesity.  It is also characteriZed by Metaplasia and Barett morphology

 (to be continued)


Genes in esophageal cancers

Mutation of Rb1
and overexpression of Cyclin D1
MSR1, ASCC1, and CTHRC1
CDK4 and CDK6

RHBDF2 gene      EGFR   MET    DLEC1

 PTGS2      FEZ1      DMBT1    p16       p14

ODC1      CDK4     CDK6     CD9      E2F

SPARC     p33   p53       Rb1     SLP1     c-MYC

 NK4    HGF     MDM2     PPRP         UPRT         p21WAF1       CIP
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