Annual Incidence 43,000 new cases a year in the United States.
Annual Mortality 35, 000, making one of the deadliest cancer in the United States.
There are suggestions that Tobacco may play a role in the Occurrence.
BRCA1 and BRCA 2 have been implicated in familial cases. Other Hereditary cases involve the HNPCC genes, p16, Ataxia Telangiectasia and Peutz-Jeghers syndrome)
KRAS, IGFR-1,DCP4, p16, p53 and BRCA2 have been implicated.
No screening method has been recommended.
The disease is clearly unresectable when Mesenteric vessels are involved or when evident metastasis are seen.
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