BASALOID TRIPLE NEGATIVE BREAST CANCER RESULT FROM A DEFECT IN GLYCOSYLATION OF RECEPTOR PROTEIN OR A FORM OF CONGENITAL EXOSTOSIS.

We know that the disease is rare like 1/5000 women
that it occurs at age 20-40 like in Polycystic kidney disease when these things develop
it changes the morphology of the cell like dysfunction of molecular membrane would
the receptor lacking post translational  modification by glycosylation will impact their binding of any growth factor  This stresses the cell which will increase further growth factor chronically to justify SECONDARY amplification PIK/MAPK.  The stress will involve particularly the TNF receptor (exostin 1) /TRAP1.
TRAP1 (Heat stroke protein) at cellular is a stimulator of c-JUN/FOS/STAT which further increase growth factor which can effectively act on their receptors.  This persistent vicious cycle leads to the neoplastic process.
Remember when c-FOS is stimulated, c-MYC is not far away to insure proliferation is rapidly started and maintained. 
The defect however start in the Golgi apparatus where Glycosylation should have occurred
and the Wnt is involved since it influences Reticulum Endothelial contact with the Golgi Apparatus!

Yes it becomes imperative to look into EXT 1,2, Retinoblastoma 1 (Rb1), and TRAP1 gene in this disease
because genetic intervention will clearly impact thousands of women. 


This analogy at Estrogen receptor, will affect other ER negative Breast cancer
It is evident that we underestimate the importance of post translational Glycosylation of Receptors in Breast cancers. BUT IT PUT HEPARAN SULFATE METABOLIC DEFICIENCY CENTER TO THIS DISEASE!

REMEMBER THE RULE THAT WHAT CAN CHANGE THE SHAPE AND DEVELOPMENT OF A MEMBRANE OR A HUMAN EXTREMITY (OR STATURE) CAN CAUSE CANCER IF DISTORTED GENETICALLY.   AND ALWAYS REMEMBER THAT A PERSONALITY CHANGE WILL BE ASSOCIATED IN MANY CASES.   CLINICIANS TREATING POLYCYSTIC KIDNEY FORGET TO INVOLVE A PSYCHIATRIST LEAVING THEIR PATIENTS GO THROUGH BROKEN MARRIAGES, PROBLEM AT WORK AND CASES OF SUICIDES!  BE UP IN THE KNOW, GIVING ACE INHIBITORS IS NOT ENOUGH!

WHAT WALKS LIKE A DUCK, QUACKS LIKE A DUCK, LOOKS LIKE A DUCK, IS PROBABLY A DUCK, I WAS TAUGHT IN MY RESIDENCY PROGRAM !