Tuesday, April 23, 2013

WHERE IS THE DOOR TO MESENCHYMAL TRANSFORMATION (where is the MEK gene) ?

In Summary,
Epithelial covers of Mucosa secrete a Mucine to protect it against infection and immune system exactions and depending on localization the MUCINE is made a different family member of MUC -x  gene, this is helpful when you have a carcinoma of unknown primary, look at the MUC gene amplified

MUC-1- lungs, stomach, intestines, eyes and several other organs (breast)

this MUC gene is more wide spread

MUC2,  Intestinal but for Pseudomyxoma (goblet cells)

MUC3A (Columnar cells)  for cancer evolving from Crohn and ulcerative Colitis,  if you are looking for association with Gallbladder Cancer, look into the MUC gene class

MUC 4 Endometrial Adenocarcinoma

MUC 5 back to lung (
Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer. Chong-Jen Yu1,; Pan-Chyr ...

MUC 6  Kidney and urogenital Mucosa (you want to know about Metastasis? I'm not Kidding?let's follow this!)

MUC 7
This gene encodes a small salivary mucin, in case you are still looking where the hell came the Adenocarcinoma from?

MUC 8  Lung and airway, but in allergy, asthma  you want to really know that this patient has an allergy, check and it is MUC 8!!!

MUC 9  human oviductin gene (protection of fallopian tube, and the embryo), but also Ulcerative colitis like MUC 3A or is it the same, let's run to the Human genome team for a consult!

MUC 10 a submandibular gland apomucin

This is fun!

MUC 11  on chromosome 7 but no interest yet!  write your paper on this one!

MUC12 
 Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohn's disease (CD).  
 etc.......
 BUT WAIT, YOU CAN START ADDING LETTERS!

The major secreted airway mucins are MUC5AC and MUC5B, while MUC2 is secreted mostly in the intestine but also in the airway.

AND JUST AS YOU START BELIEVING IT IS ALL SIMPLE!  COMES THE CRUSHING NEWS:
YOU reach the door of MESENCHYMALIZATION when you reach MUC-20, this is where epidermal and endothelial switch, where squamous switch to adenocarcinoma, where the MEK gene is located!
AND REMEMBER WITH THE MEK GENE COME ANGIOGENESIS!  THAT'S WHY ANTI-MEK WORK WHERE AVASTIN STOPS OR I SHOULD SAY ONE LEADS TO THE OTHER'S ACTIVITY!

AND IF YOU CONTINUE THIS DANCE, YOU WILL FIND THAT SOME MUC GENE BECOME SPECIFIC TO SOME OTHER SPECIES, WE DON'T MAKE THEM!

ONCE AGAIN FROM SIMPLE THINGS, IT GET COMPLICATED REALLY FAST!
NATURE...RESPECT IT!

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