CRBCM IS NOT THE ONLY ONE DISCUSSING ALZHEIMER, CHECK-OUT MEDSCAPE


"Jacques Hugon, MD, PhD, Professor of Neurology at Saint-Louis Lariboisière Fernand-Widal Hospital in Paris, France, about a biomarker with the potential to aid in AD diagnosis. It's not amyloid beta or tau.
Medscape: Dr. Hugon, what can you tell us about PKR?
Dr. Hugon: PKR is a kinase that has been shown to play a role in recognizing and signaling viral infection, but its activity has also been shown to be altered in several neurologic disorders in which it negatively modulates memory.^[1] Once overactivated, PKR becomes a toxic kinase. As we have shown in our study,^[2] PKR accumulates in the brain of patients with AD and can induce the death of neurons. We have seen that the PKR level in the cerebrospinal fluid (CSF) and the activity of PKR in the brain are highly elevated in patients with AD compared with non-AD patients. Our study showed that the mean level of PKR and phosphorylated PKR in the CSF was 300% higher in patients with AD. Sensitivity was 91.1% and the specificity was 94.3%."

BUT IS THIS AS GOOD AS S100B OR SIMPLY THE METALLOPROTEASES?   A CLINICAL TRIAL IS NEEDED!