Does malignant transformation established once permanently PTEN is depressed, or is it when c-MYC is amplified? or is it when receptors are permanently desensitized? is glycosylation of receptor protein or lack of,  the permanent trigger  of neoplastic transformation? will discuss further these topics!
Activation of P53 and mutation of mutation of Rb1.
EGFR amplification could be secondary to blockage at its receptors
PDGFRA amplification also
HOX gene
or mutation at the Meis1 and equivalent genes
No matter what cancers, these events may happen.
We will delve on these paths.