Tuesday, April 16, 2013

FROM SIMPLE TO COMPLICATED IN CELLULAR FUNCTION.

The finding of CORE BINDING FACTOR (CBF) has been one of the best finding in modern cellular biology
and my analogy will be that CBF is a BENCH or a room full of purpose!
Let explain this by taking the current international crisis situation where north Korea wants to wage a war against its neighbors and the united states.  And the cell wants to resolve this issue.
For that, the cell will create a BENCH or a Room with 4-5 seating places

for A the united states    (TK1)
and B north Korea         (TK2)
but also C china             (RTK1)
and D south Korea        (RTK2
and may E FOR JAPAN  (BUS1)

Corresponding seats will be called A', B', C', D' and E'

The bench or room will have these 5 seats ready, and in due time
the 5 will come to sit in the order predetermined by the the Bench preparer, Negotiation will occur and resolution of the conflit will occur.

If  you understand this then you know how the cell can control the metabolism.

The Bench or room is the CBF
and Activity from that bench or room will result in Chronic Myelogenous leukemia or war.

Instead of China, let send CONGO to spoil the meeting and let is sit at C'
CONGO has no clue about the issue and will spoil the meeting.  That is what Gleevec does.

Gleevec attaches where a leukemia inducing protein should attach.  And Nilotinib attachment to the China seat 30 times stronger.  Dasatinib, the manufacturer refuses to tell us!

NOW any changes of C' (the seat) may make the person sitting uncofortable and not work as planned creating resistance to the drug.

The core Binding factor or Bench, a easy thing to understand but causing leukemic mayhem !

FOR THE CURE, KNOW ALL THE CBF IN A CELL AND PICK THE ONE TO SPOIL AND YOU GOT IT!

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