DIFFERENTIATION AND CANCER CURE II

Since our primary objective is to find "natural ways" for the cure.  How does differentiation fit into the strategy.  We have described how Differentiation is linked to suppression or silencing of certain genes (WT1), and over-expression of other (specific transcription factors or types of RAS).  The cell under differentiation shows us how to do it to control gene expression (various pattern of Methylation).  Even the location of the differentiation Vs another location where this differentiation does not occur, gives us local environmental conditions prohibiting such differentiation (why wings on the back and not the front).  What environment makes the cell tick is important in Hematologic cancers.

The other opportunity that differentiation offers is that it bring natural cell death to even the cancer cell.  Indeed full differentiation renders the cell susceptible to turn over mechanisms which includes Apoptosis.
The notion that amount of methylation is important for cell survival bring an interesting notion that we should be quantifying this parameter and registering pattern to differentiate cancer cells from normal cell. and that selective demethylation could be curative.

When you block differentiation, specific tissue development may be compromised all together. In such formed tissue, could blocking these tissue differentiation molecules affect more proliferating cells? Certain differentiation (Mucin production) are protective for the cancer (TIM-3).  Silencing or antibody receptor to related growth factor allow for a weaker cancer.   Can we switch differentiation of cancer cells into easier cancer to treat through manipulation of growth factor or alteration of splicing sequence or quantitative or qualitative change of transcription factors.  By gene Knock out or silencing, can we either commit cells to full differentiation or remove cells ability to go back to a proliferative state....

Genes of Differentiation
WT 1
OCT4
SOX 4
KLF4
MYC
NANOG
PRC2
WINT
STAT3
NGF
Variable genes
RAS
CK5,6
YB-1
Nomenclature comment to follow