Friday, December 14, 2012

ANOIKIS, detachment induced cell death

Review: Nature Reviews Cancer 7, 429–440 (1 June 2007) |

The cofilin pathway in breast cancer invasion and metastasis

Weigang Wang , Robert Eddy & John Condeelis
Recent evidence indicates that metastatic capacity is an inherent feature of breast tumors and not a rare, late acquired event. This has led to new models of metastasis. The interpretation of expression-profiling data in the context of these new models has identified the cofilin pathway as a major determinant of metastasis. Recent studies indicate that the overall activity of the cofilin pathway, and not that of any single gene within the pathway, determines the invasive and metastatic phenotype of tumor cells. These results predict that inhibitors directed at the output of the cofilin pathway will have therapeutic benefit in combating metastasis.
Post a Comment