Wednesday, December 19, 2012

NON-CASPASE WAY TO CELL DEATH
ONE OF THE WAYS CELLS DIE WHICH IS NON-CASPASE DRIVEN MAY RESULT FROM DISRUPTION TO THE CONCENTRATION OF THE CYTOSOL OR SOLUTION WITHIN THE CELL.   HOMEOSTASIS REQUIRES THAT SOLUTION TO BE SET AT A CERTAIN CONCENTRATION IN TERMS OF ELECTROLYTES, OXYGEN AND PH.  THE CELL HAS ION PUMPS TO MAINTAIN ELECTROLYTE CONCENTRATION.  ELECTIVE DISRUPTION OF ION PUMPS WILL LEAD TO DISRUPTION OF CONCENTRATIONS THAT MAY SEND DEVASTATING BLOW TO THE CELL.   WATER GOES FROM LESS CONCENTRATED TO MORE CONCENTRATED ENVIRONMENTS.  THIS IS A POWERFUL KNOWN LAW OF NATURE.  IN CLINICAL PRACTICE, WE DON'T USE THIS LAW ENOUGH.  NOT BECAUSE IT IS NOT REAL
BECAUSE THIS IS HOW DIABETES KILLS ITS VICTIMS.  THIS IS HOW DEHYDRATION KILLS AND SO ON.   OUR CHALLENGE HAS BEEN HOW TO ELECTIVELY USE IT TO ATTACK ONLY CANCER CELLS.  FOR THIS WE NEED TO FIND OUT IF IONS PUMPS FROM CANCER CELLS ARE DIFFERENT FROM THOSE OF NORMAL CELLS.

(TO BE CONTINUED)
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