Understanding the Laws of Biology

IMPORTANCE OF UNDERSTANDING BIOLOGIC LAWS

With every research performed around the world, scientists learn a little more.  It is important that research focuses on a particular molecule and its interactions, specificity and efficacy. Point location research should be understood within a general plan of advances in biomolecular research.  To find that, TGF Beta, when produced, will make a cancer grow and therefore make the cancer more resistant to treatment, is nice. It adds to the detailed knowledge.  TGF(s) act on membrane receptors, therefore it will harvest the signal pathways to display its might.  We know that it will reach or may emanate from some transcription genes.  The tract its actions have to follow to affect the cell is full of loopholes and pitfalls.  Going after TGF(s) should be part of a planned combination approach.  It cannot work in over 30% of the people because of genetic heterogeneity which in itself is nature's protection for host survival.

Here at CRBCM, we understand that to cross the 50% effectiveness, our current treatment strategies must include the activity of the 2nd law well described here.  And better yet the first 2 laws.  Disruption of gene, and that of Microtubule that will lead to caspase release (Cytochrome c disruption implied).  Membrane based effects are only as good as they are able to involve an increased activity of fas and Bax.  Short of that, they are 70% ineffective.  (You can't discount 30% though)

TGF could present an opportunity for treatment.  We made an early allusion to the JUDO.  Use the power of the attacker to send him to the floor "in the general direction of his attack".  TGF wants to achieve acceleration of growth and cellular multiplication.  Disruption of gene and microtubule may in fact be more effective when faster multiplication is achieved? This is risky, but not a crazy a approach.  That is also why chemotherapy works only on dividing cells!

Globally, however, TGF and Bcl-2 tend to protect cancer cell. TGF seems to give a growth advantage to cancer cells vis-a-vis surrounding cells.  Bcl-2 seems rather to be a protection mechanism from reaching the mitochondrial Caspase,  protecting therefore cancer cell from Apoptosis, the cure to cancer. 
With this background info, we can now judge any research coming along as to its importance, and see how it fits in the general strategy to achieve the cure we all want.