Thursday, May 23, 2013

MITOCHONDRIAL TARGETS

BESTWICK et al
"The human genome comprises large chromosomes in the nucleus and mitochondrial DNA (mtDNA) housed in the dynamic mitochondrial network. Human cells contain up to thousands of copies of the double-stranded, circular mtDNA molecule that encodes essential subunits of the oxidative phosphorylation complexes and the rRNAs and tRNAs needed to translate these in the organelle matrix. Transcription of human mtDNA is directed by a single-subunit RNA polymerase, POLRMT, which requires two primary transcription factors, TFB2M (transcription factor B2, mitochondrial) and TFAM (transcription factor A, mitochondrial), to achieve basal regulation of the system."

DO YOU REALIZE THAT ATTACKING ELECTIVELY FACTOR A OR /AND B COULD RIG THE ALL RESPIRATORY SYSTEM OF THE CELL?DAMN!

WHAT ABOUT DIABETES?
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GABALLA et al.


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  • In addition, eccentric left ventricular geometric patterns, detected by echocardiography, and renal hypertrophy, revealed by ultrasonography, are promising new markers predicting DN development.
  • Serum and urinary markers are still invaluable elements, including serum uric acid, microalbuminuria, macroalbuminuria, urinary liver–type fatty acid–binding protein (u–LFABP), and urinary nephrin.
  • Moreover, studies have illustrated a tight relationship between obstructive sleep apnea and the development of DN.
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