*Fulvestran at 500 mg is probably the strongest hormone intervention in post Menopausal patients.
*Switching from Letrozole to tamoxifen after 2 years has NO loss in survival benefit, so if Osteoporosis is worsened on Letrozole, switch easy!
*Docetaxel +Herceptin+Pertuzumab is best first line treatment of Her-2 positive metastatic breast cancer .
*Don't give T-DM1 with Herceptin because they compete for same receptor and mitigate the power of T-DM1
*Tamoxifen has a "carry over" effect. Even when you stop it, it keeps on going (like the Battery!)
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