CANCER CELLS OPERATE IN THE "STRESS MODE"

KNOWING THE FACT THAT IT MAY NOT MEET ITS ENERGY REQUIRED TO UNDERGO ALL ITS NEW FUNCTIONS CALLED FOR BY ITS TRANSFORMATION, CANCER CELLS TURN ON THEIR STRESS "MODE". ON TOP OF PUTTING IN PLACE MECHANISMS TO ESCAPE IMMUNE SURVEILLANCE, TOLERATE GENETIC ABNORMALITIES BY PARALYZING AMONG OTHER THINGS P53, THE CANCER HAPPENS TO FUNCTION IN SOMEWHAT A "HYPOXIC" MOOD.

AND THEN YOU READ THIS!

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1alpha in hepatocellular carcinoma Full Text
BMC Cancer, 05/18/2013  Clinical Article

Zhang L et al. – In this study, the authors investigate the molecular mechanism by which hypoxia promotes hepatocellular carcinoma (HCC)invasion and metastasis through inducing epithelial–mesenchymal transition (EMT). They demonstrated that hypoxia–stabilized HIF1alpha promoted EMT through increasing SNAI1 transcription in HCC cells. This data provided a potential therapeutic target for HCC treatment."

AND YOU KNOW CANCER WILL BE ON THE MOVE SOON

BECAUSE THIS IS THE WAY TO ENDOTHELIAL TRANSFORMATION AND WITH ENDOTHELIAL TRANSFORMATION COMES MOVEMENT OF CELLS TOWARD ORGAN RIPE FOR SEEDING! YES WITH ENDOTHELIAL TRANSFORMATION, THE E-CADHERIN IS SUPPRESSED, RECEPTORS OF THE CELLS CHANGE IN NATURE AND THE CELL RELEASE SOME OF THE ADHESION PROTEINS, AND IT IS ON THE MOVE!  IN THIS MODE, IT WILL BE ALSO LESS DEPENDENT TEMPORARILY ON ITS GROWTH FACTORS!

AND WHAT GENES COMES WITH ALL THIS ENDOTHELIAL TRANSFORMATION?

RBSP3, HYA 22, APO22, APRG1, ITGA2, VILL (SMAD AND CDK9 ARE IN THE WING)

YOU JUST KNOW SOMETHING IS BIG CELL WISE WHEN RNA POLYMERASE IN INVOLVED BECAUSE DNA POLYMERASE FOLLOWS WITH THE REST OF THE KITTEN CABOODLE THAT LEADS TO NEW PROTEIN FORMATION THAT WILL IMPACT CELLULAR METABOLISM ! MEK IS SOMEWHERE ACTING TOO...