Thursday, May 2, 2013

INTERESTING CLINICAL VISIT AND QUESTION
IS IT TRUE THAT MUIR TORE AND MAY BE ALSO LYNCH SYNDROMES CAN BE EXACERBATED BY EMBREL USE?
WE NEED TO FURTHER INVESTIGATE THIS
CAN A PATIENT WITH RECURRENT SEBACEOUS CANCER OF THE SKIN RECEIVE EMBREL FOR TREATMENT?

The MUIR-TORRE results from alteration in function of mis-match repair genes particularly the MLH1 and the MSH2.  It belongs to the Lynch family of Syndromes affecting mostly the GI track but also many other organs including the brain!
Downstream from the MLH1 are  ATR, BRCA-1, CHEK-2,EXO1, MAX,MSH3, MSH6,P53 genes
AND DOWNSTREAM MLH2  are EXONUCLEASES, PMS2,MSH4,MYC, BLOOM SYNDROME PROTEIN, MBD4 (REMEMBER MBD4 IS UPSTREAM FROM FADD)

One the other side is EMBREL an anti-TNF
where is the intersection ?
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