Monday, May 20, 2013

RENEWED INTEREST IN CDK-9

Cyclin-dependent kinase 9

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Cyclin-dependent kinase 9

Rendering based on PDB 1PF6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDK9; C-2k; CDC2L4; CTK1; PITALRE; TAK
External IDs OMIM603251 MGI1328368 HomoloGene55566 ChEMBL: 3116 GeneCards: CDK9 Gene
EC number 2.7.11.22, 2.7.11.23
RNA expression pattern
PBB GE CDK9 203198 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1025 107951
Ensembl ENSG00000136807 ENSMUSG00000009555
UniProt P50750 Q99J95
RefSeq (mRNA) NM_001261 NM_130860
RefSeq (protein) NP_001252 NP_570930
Location (UCSC) Chr 9:
130.55 – 130.55 Mb
Chr 2:
32.71 – 32.71 Mb

PubMed search [1] [2]
Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.[1] CDK9 is also known to associate with other proteins such as TRAF2, and be involved in differentiation of skeletal muscle.[2]


Interactions

CDK9 has been shown to interact with Cyclin K,[3] Cyclin T2,[4] RELA,[5] Cyclin T1,[3][4][6][7][8][9][10][11][12] Retinoblastoma protein,[13] Androgen receptor,[14] SKP1A,[10] MYBL2,[11] CDC34[10] and SUPT5H.[12]

(TO BE CONTINUED!)
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