Thursday, May 16, 2013

MORE VARIOUS NEWS

*According to a report by Alice Goodman, a higher expression of Her-2 was linked to best results with T-DM1.
This was concluded from the EMILIA trial.

*Full node dissection after positive sentinel is raising controversy among Surgeons involved in the discussion for its value!
Proponents maintained that:
1. Full node dissection  has staging value
2. Full node dissection decreases regional recurrence risk

Opponents maintain:
- It is an unnecessary and costly operation because 80% of pt with positive nodes have distant disease anyway
- Lymphedema risk worsens particularly with groin dissection
- Increased infection risk and nerve damage potential
that good result is linked to patient selection
- FULL DISSECTION DOES NOT INCREASE SURVIVAL.

HOWEVER, GAMBLING WITH MELANOMA IS A LITTLE MORE RISKY THAN IN BREAST CANCER. THE DIFFERENCE OF PROGNOSIS IN METASTATIC DISEASE TELLS IT ALL!  THE LACK OF DIFFERENCE IN SURVIVAL IS HOWEVER A SIGNIFICANT HURDLE TO CONCUR!

Post a Comment