DESPITE THE FACT THAT THE NOTCH PATHWAY IS CRITICAL IN THE NORMAL FUNCTION OF THE PANCREAS, A FEW TREATMENTS AIMING AT PARALYZING THE NOTCH DID NOT WORK EITHER BECAUSE THEY DID NOT EFFECTIVELY DISABLE IT, OR BECAUSE THEY COULD ONLY OPEN UP THE DOOR TO SUSCEPTIBILITY OR REFRACTORINESS TO DRUGS THAT SUBSEQUENTLY WERE NOT GIVEN.
NOW WE KNOW WHY ANTI-VEGF BY THEMSELVES DO NOT WORK (TUMOR OVER EXPRESSION OF VEGFR2 ?DECOY).
WE SHOULD REMEMBER THAT MAIN THE PATHWAYS THERE ARE NOT HEDGEHOG, NOTCH OR ANGIOGENESIS, BUT CLEARLY RECEPTOR FAILURE AND SUBSEQUENT UPSET OF THE NF-kB...(IN PANCREATIC CANCERS) . THE NOTCH, HOWEVER, INTERVENES IN THE PAIN THIS CANCER GIVES!
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