AURKA GENE/ AN INDICATION FOR TAXANES?
"Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations^[4] and its activity peaks during the G2 phase to M phase transition in the cell cycle.<sup>[5]"WIKIPEDIA

"Aurora A is critical for proper formation of mitotic spindle. It is required for the recruitment of several different proteins important to the spindle formation. Among these target proteins are TACC, a microtubule-associated protein that stabilizes centrosomal microtubules and Kinesin 5, a motor protein involved in the formation of the bipolar mitotic spindle.[4] γ-tubulins, the base structure from which centrosomal microtubules polymerize, are also recruited by Aurora A. Without Aurora A the centrosome does not accumulate the quantity of γ-tubulin that normal centrosomes recruit prior to entering anaphase. Though the cell cycle continues even in the absence of deficient γ-tubulin, the centrosome never fully matures; it organizes fewer aster microtubules than normal.[5]"WIKIPEDIA

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Aurora A dysregulation has been associated with high occurrence of cancer. For example, one study showed over-expression of Aurora A in 94 percent of the invasive tissue growth in breast cancer, while surrounding, healthy tissues had normal levels of Aurora A expression.^[4] Dysregulation of Aurora A may lead to cancer because Aurora A is required for the completion of cytokinesis. If the cell begins mitosis, duplicates its DNA, but is then not able to divide into two separate cells it becomes an aneuploid- containing more chromosomes than normal. Aneuploidy is a trait of many cancerous tumors.^[7] Ordinarily, Aurora A expression levels are kept in check by the tumor suppressor protein p53.^[4]
Mutations of the chromosome region that contains Aurora A, 20q13, are generally considered to have a poor prognosis.<sup>[4]WIKIPEDIA"

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AGENTS THAT ACTIVATES P53 WILL HAVE A STRONGER EFFECT IN THESE CANCER AS THEY WILL SUPPRESS THE AURORA A
AND SHOULD MORE LIKELY COMBINED TO TAXANE AS IT ACTS ON MICROTUBULES?</sup>