Known Targets in Sarcoma and various malignancies!
*"In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells.In
breast cancer research CD44+/CD24- expression is commonly used as a
marker for breast CSCs and is used to sort breast cancer cells into a
population enriched in cells with stem-like characteristics.[15] and has been seen as an indicator of increased survival time in epithelial ovarian cancer patients.[16]
Endometrial cells in women with endometriosis demonstrate increased expression of splice variants of CD44, and increased adherence to peritoneal cells.[17]
CD44 variant isoforms are also relevant to the progression of head and neck squamous cell carcinoma.[18][19]
Monoclonal antibodies against CD44 variants include bivatuzumab for v6." wikipedia
*
-----------------------------------------------------------------------------------------------------------
TEC
Very significant target because down the stream of this gene is
DOK1,and most impressively ARHGEF which has activity with 2 well
recognised therapeutic targets CD44 and P110 alpha, remember P110alpha
deficiency can induce Malformation (Macrocephaly) and you know how we
feel about gene inducing malformation
" non-receptor protein-tyrosine kinases containing a pleckstrin homology
domain. Tec family kinases are involved in the intracellular signaling
mechanisms of cytokine receptors, lymphocyte surface antigens,
heterotrimeric G-protein coupled receptors, and integrin molecules. They
are also key players in the regulation of the immune functions. Tec
kinase is an integral component of T cell signaling and has a distinct
role in T cell activation. This gene may be associated with
myelodysplastic syndrome.[2]wikipedia
Anti CD44 has just been used in a recent publication
adding a booster of c-AMP may intensify the effect (PRKAR1A related).
No comments:
Post a Comment