GET A LITTLE DIRTY MAY BE GOOD FOR YOU!

I know coming from a health professional it is somewhat surprising or even shocking, but take a moment and read about this statement!

ALLERGIES ARE ON THE RISE!

"The increase in allergic diseases noted in the last 2 decades is thought to result from better hygiene conditions, decreases in infant and childhood infections,and an increasingly sedentary and indoor lifestyles." (Wasserman)
yes the less you have been exposed to antigen the more likely you could become allergic.  You have not challenged your innate immune system enough.  The author suggest that this fact somehow "alters the protective maturation of the acquired immune system".  Now this statement is heavy in implications!  It implies that the development of class II Major Histocompatibility (MHC) is some what influenced in their development by class I Antigen? or am I over-reaching?
Innate immune system is Tolerance of self Antigens?  Acquired Immunity is the stuff mostly class II antigens deal with!
Challenging this statement, will need to read more about this!  At CRBCM, we like this form of challenge! keeps one with sharp mind!
This is germaine to genetics because its throws you next into methylation of genes involved in immunity!
Indeed the "Hygiene Hypothesis" suggested switch off of T2H was not fully completed in favor of T1H...Methylation could have been the silencing mechanism!? check this out!