AGE RELATED EXPRESSION OF DEFICIENT GENE

Although one may have deficient gene,death from its consequences varies based on how critical lack of expression is to the body. Lack of function in a critical tissue leads rapidly to death. Expression of a deficient gene depends on whether it it dominant or recessive, and whether one is homo or heterozygotic as related to the gene in question.  many diseases of genetic basis express themselves at a letter stage in life.  Polycystic Kidney disease for example gives its full blown syndrome only after 30 years of age, and starts worsening  to finally take the life of the bearesr in  their 5th ot sixth decade of life. Althto though one cannot say for sure what intervened with age for the syndrome to fully express, we know that immune and hormonal developments contribute significantly to this unfortunate unfolding.
We know that in infectious processes we encounter as we age, there is disturbances of Interferons levels, and if one has an autoimmune disease, these interferon levelsare somewhat permanent or constant.  Interferon activate T cell and boost Immunity but also secondarily immune system surveillance of cancer occurrence. This interferon seems linked to Class I histocompatibilty HLA-A,B,C.

In Women however, as they age and enter reproductive age, there is need to suppress class I HLAin order to "tolerate" a child/fetus.  It is assumed that a vague of hormone driven gene methylation seems to be the mechanism.  Gene methylation will silence many genes and could potentially silence normal genes that where conterbalancing the gene defect.  Defectuous genes will this way get there chance to finally express themselves and cause progression of syndromes thay can cause.  Androgenic development in males achieves the same deterioration.  Giving Azacytidine had reversed these methylation by the way although clinical trials are still ongoing on whetehr it can meaningfully change the course of these gene based diseases.That is before irreversible tissue damage sets in.