Friday, June 28, 2013

NEW STRATEGIES TO FIGHT HYPERTENSION AT GENETIC LEVEL

WATCH BARTER'S AND GITELMAN'S SYNDROMES! (SEE WIKIPEDIA)
IN THIS DISEASE, HYPERTENSION DOES NOT OCCUR!   THE ONLY DANGER IS OF COURSE DEAFNESS SO KEEP AWAY FROM CLCNK A and B  (CIC-kB), ALL OTHER ARE TARGETABLE, OF COURSE DO NOT REPRODUCE THE FULL DISEASE, CHALLENGES  AHEAD BUT DON'T RULE IT OUT JUST YET!

Bartter and Gitelman syndromes can be divided into different subtypes based on the genes involved:[5]
Name Bartter type Associated gene mutations Defect
neonatal Bartter's syndrome type 1 SLC12A2 (NKCC2) Na-K-2Cl symporter
neonatal Bartter's syndrome type 2 ROMK/KCNJ1 thick ascending limb K+ channel
classic Bartter's syndrome type 3 CLCNKB Cl- channel
Bartter's syndrome with sensorineural deafness type 4 BSND[6] Cl- channel accessory subunit
Bartter's syndrome associated with autosomal dominant hypocalcemia type 5 CASR[7] activating mutation of the calcium-sensing receptor
Gitelman's syndrome - SLC12A3 (NCCT) Sodium-chloride symporter
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