HYPOTHESIS IN THROMBOSIS!

THE NOTION THAT INFLAMMATORY BOWEL DISEASE (IBD) CAN BE EXACERBATED BY
NON STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID), opens the door to speculation that in a certain set of patients, NSAID can precipitate a catastrophic event including stroke and heart attack or sudden death syndrome.
IBD seems to include a thrombostatic state full of risk for  thrombosis formation therefore the hypothesis  does not seems far fetched.  In patients with IBD, the level of IL23 seems to be elevated.  And the disease appears to be linked to this.   IS THERE JUSTIFICATION TO RECOMMEND THAT BEFORE PUTTING PATIENT ON aSPIRIN, THAT THE LEVEL OF INTERLEUKIN-23 BE TESTED?
IT HAS BEEN ALSO SUGGESTED THAT THE EXACERBATION OF IBD IS DUE TO THE SUPPRESSION OF A COUNTER-BALANCING CYTOKINE, MAY BE INTERLEUKIN-4.  SHOULD WE BE MONITORING LEVEL OF INTERLEUKIN-4 TO PREDICT THE RISK OF FURTHER THROMBOSIS IN CORONARY ARTERY DISEASE? IS HIGH INTERLEUKIN-4 PROTECTIVE OF FURTHER THROMBOSIS?  WHAT CAUSES EXTENSION OF THROMBOSIS?