TRANSGENDER?

CNN PRESENTED LAST NIGHT: FROM CHRIST TO CHRISTIN, THE STORY OF A MAN WHO HAS GONE TROUGH A "NAVY SEAL" TO A TRANSGENDER WOMAN CURRENTLY ESTROGEN TREATMENT, AND WANTING TO LIVE AS "JUST ANOTHER WOMAN AROUND THE CORNER". THE STORY WAS FASCINATING, AND SOMEWHAT DIFFICULT FOR THE REPORTER WHO COULD NOT LOOK AT "CHRISTINE" IN THE EYE AS MUCH AS CHRISTINE DID!
THIS STORY DID BRING TO MIND ALSO A WEIRD QUESTION THAT POPPED UP ONE DAY BEFORE A CONFERENCE: A TRANSGENDER WOMAN HARD AT WORK ON ESTROGEN TREATMENT, SHOW-UP WITH AN ADVANCED PROSTATE CANCER, QUESTION WAS HOW TO TREAT?
BUT LET GO BACK TO THE GENETIC BASIS OF "TRANS-SEXUALITY" 
THIS FIELD IS CONTROVERSIAL, WITH PSYCHOLOGISTS FIGHTING TO CONSIDER THIS A STRICTLY BEHAVIORAL WHEN GENETICISTS MAINTAIN IT IS STRICTLY A GENETIC DISTURBANCE.
MY FAVORITE THINKING IS THAT IT IS A FAILURE OF METHYLATION OF CRITICAL HORMONAL GENES, BUT OTHER MAINTAIN IT IS AN ABERRATION OF A GENES WHICH IS CHARACTERIZED BY AN ATTACHMENT OF A PROLONGED REPEAT OF MOLECULES.
THERE IS NO FUMES OR SMOKE (IF YOU WANT A LIGHTER OPTION) WITHOUT A FIRE I WANT TO MAINTAIN, SO I LEAN FOR A GENETIC BASIS TO THIS ARGUMENT.
WIKIPEDIA:
"

Genetics

The androgen receptor (AR), also known as NR3C4, is activated by the binding of testosterone or dihydrotestosterone, where it plays a critical role in the forming of primary and secondary male sex characteristics. Hare et al. found that male-to-female transsexuals were found to have longer repeat lengths on the gene, which reduced its effectiveness at binding testosterone.^[18]
A variant genotype for a gene called CYP17, which acts on the sex hormones pregnenolone and progesterone, has been found to be linked to female-to-male transsexualism but not MTF transsexualism. Most notably, the FTM subjects not only had the variant genotype more frequently, but had an allele distribution equivalent to male controls, unlike the female controls. The paper concluded that the loss of a female-specific CYP17 T -34C allele distribution pattern is associated with FtM transsexualism.^[19]"
  Currently, there are numerous scientific explanations of the cause of transsexualism, linking the cause to genetics, brain structure, brain function and prenatal androgen exposure; in addition, other theories have proposed linking the cause to psychological and behavioral reasons. These theories are not necessarily mutually exclusive."