GENETIC MELI-MELO IN BREAST CANCER MEDICINE

There are now no questions that autoimmune syndromes are closely linked to cancer development
Inflammatory breast cancer-IBC is really linked to Inflammatory processes as 80 percent of IBC have under-expression (or repression) of genes under significant interferon gamma and TNF influence.  INTERFERON ALPHA which is amplified in autoimmune diseases.   Indeed abnormality at WISP3 id found in 60-80% of IBC!

Interferon negative effect on CTGF depent on an intact expression of JAK-2.

chemotactic activity of WISP3 but not CYR61 was mediated through integrin ανß5.(schuze et al)

(recombinant angiopoeitin2 could boost Avastin role in diabetic retinopathy)