GENE CASCADE SHOWING PATHO-PHYSIOLOGY IN BREAST CANCER


                                                 TGF
                                                    !
                                                    !
                                                    !(WISP3/CCN6-FOR INFLAMMATORY
                                                    !  BREAST CANCER)
shRNA----------------------------CTGF/CCN2---------ANGIOGENESIS! PROLIFERATION
                                      !               !                                      
                                      !               !
                                      !               !
                                      !            JAK-2
                                      !               !
                                      !               !
                                  TNF a       INTERFERON gamma---E-CADHERIN,CD44
                                      !               !
                                      !               !
                                     ESTROGEN