wikipedia, Stanniocalcin-1 is a " glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. Human Stanniocalcin-1 is a putative molecular biomarker of leukemic microenvironment and the only molecular function known up to date is a SUMO E3 ligase activity in the SUMOylation cycle. STC1 interacts with lots of proteins in the cytoplasm, mithocondria, endoplasmatic reticulum and and dot-like fashion in the nucleus. The N-terminal region of STC1 is the function region which is responsible to establish the interaction with its partners, including SUMO1.[3"
Researchers" found a dramatically upregulated expression of STC during induced neural differentiation in a human neural crest-derived cell line", Paju.(Zhang et al)
"Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.[2]wikipedia".
Tamura "
"The relative expression levels of the STC1 gene were higher in the cancer tissue than in the normal adjacent mucosa and high expression of STC1 correlated with poor postoperative survival.
CONCLUSION:
High expression of the STC1 gene might be a useful predictor of poor postoperative outcome in patients with colorectal cancer."GUO: " Here, we found that STC1 is down-regulated in Clinical tissues of cervical cancer compared to the adjacent normal cervical tissues (15 cases). Subsequently, the expression of STC1 was knocked down by RNA interference in cervical cancer CaSki cells and the low expression promoted cell growth, migration and invasion."
ASIDE FROM IT BEING A CLEAR TARGET FOR INTERVENTION IN CANCER, THIS GENE SEEMS TO AFFECT AN IMPORTANT COMPONENT OF MICROFIBRILLARY TANGLES THAT CHARACTERIZE ALZHEIMER DEMENCIA, WHICH IS SHIFT IN CALCIUM PHOSPHATE RATIOS. IT BEGS A QUESTION : WHAT IS THE ROLE OF STC1 IN ALZHEIMER DISEASE?
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