STRONG GENES ARE ASSOCIATED WITH MALFORMATIONS
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Times and times again in the life of this blog, we continue to stress that the power of a gene is revealed when its deficiency, lack of function or mutation leads to a Malformation.  Another example of this is the Androgen or steroid related gene.  Women with Inflammatory bowel disease who are pregnant and given steroids have either early/premature rupture of membranes and/or their infants have a higher rates of cleft lip!

TISSUES SHARE SAME GENES !
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Whenever you target a gene with target therapy treatment, always keep in mind that genes are the same in all cells!  Patterns of gene silencing in various tissues determine the expression of same genes in various tissues.  And do remember that some mechanisms of silencing are irreversible and some are reversible. It is interesting that in irreversible cases not only the cell knows that the gene is silenced it keeps memory of this, meaning de-methylation of some genes in a particular tissue has no effect into new expression of that gene, as if not only the cell Methylate a gene to silence it, it also remove proteins that helps its expression once demethylated!
It is striking that expressed genes finding themselves targeted by therapy in the white blood cells, are also active in the brain and liver, leading to liver failure and and various Central Nervous system (CNS) side effects ranging from coma to LEUCO-ENCEPHALOPATHY! IT IS UNCLEAR WHETHER STUDYING THE LEVER OF AMPLIFICATION OF TLE4, OR STATUS OF THE GROUCHO FAMILY MEMBER COULD HELP PREDICT WHO WILL MORE LIKELY DEVELOP CNS SIDE EFFCT!